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Convinced that his wayward brother Lincoln Burrows was wrongly convicted of the sensational murder of the President's brother, which landed him on Fox River State Penitentiary's death row, a desperate Michael Scofield attempted a daring bank robbery in order to get himself incarcerated in Fox River with Lincoln. Michael, an engineer with access to the prison's structural design, then masterminded an elaborate plan to free Lincoln by pulling off the ultimate prison break.
Aided by an intricate tattoo of the prison's blueprints covering his upper body, Michael aligned himself with his lovelorn cellmate Fernando Sucre, former mob boss John Abruzzi, homicidal pedophile Theodore "T-Bag" Bagwell, the well-connected Benjamin Miles "C-Note" Franklin, and Charles Westmoreland, a man Michael believed to be the infamous skyjacker D.B. Cooper. On the outside, Michael's only ally was his defense attorney and Lincoln's former girlfriend Veronica Donovan, who protected Lincoln's targeted son LJ. Veronica's quest for the truth led straight to the White House, Secret Service Agent Paul Kellerman and the power-hungry President, Caroline Reynolds, whose brother, in secret, is very much alive.
Overcoming many setbacks, the brothers and six other inmates ultimately escaped from Fox River. The prison break had its consequences, however - Michael was forced to betray his father figure, Warden Henry Pope; prison doctor Sara Tancredi, who was instrumental in the escape plan and had romantic feelings for Michael, relapsed with drugs and overdosed; and Westmoreland died of injuries sustained in the escape, but not before revealing that he was indeed D.B. Cooper - and providing a clue to where he had hidden over $5 million in cash.
Outside the prison walls, the escape truly begins as the convicts race for their lives - and the hidden cash - while trying to avoid capture by the authorities. The pursuers are led by vengeful prison guard Captain Brad Bellick, who, driven by a personal vendetta, will stop at nothing until the escapees are captured or killed. [ more ]

Cast:
Dominic Purcell ••••• Lincoln Burrows
Wentworth Miller ••••• Michael Scofield
Amaury Nolasco ••••• Fernando Sucre
William Fichtner ••••• FBI Agent Alexander Mahone
Robert Knepper ••••• Theodore "T-Bag" Bagwell
Wade Williams ••••• Captain Brad Bellick
Marshall Allman ••••• LJ Burrows Jr.
Robin Tunney ••••• Veronica Donovan
Peter Stormare ••••• John Abruzzi
Paul Adelstein ••••• Agent Paul Kellerman
Sarah Wayne Callies ••••• Dr. Sara Tancredi
Stacy Keach ••••• Warden Henry Pope
Danny McCarthy ••••• Agent Danny Hale
Muse Watson ••••• Charles Westmoreland
Rockmond Dunbar ••••• Benjamin "C-Note" Franklin
Frank Grillo ••••• Nick Savrinn
Lane Garrison ••••• David "Tweener" Apolskis
Silas Weir Mitchell ••••• Charles "Haywire" Patoshik
Patricia Wettig ••••• President Caroline Reynolds
John Heard ••••• Governor Tancredi
Kristin Lehman ••••• Jane Barrow
Reggie Lee ••••• Agent Bill Kim
Leon Russom ••••• The Pad Man
Danay Garcia ••••• Sofia Lugo
Robert Wisdom ••••• Lechero
Chris Vance ••••• James Whistler
Jodi Lyn O'Keefe ••••• Susan B. Anthony/Gretchen
Creators:
Paul T. Scheuring, Matt Olmstead, Kevin Hooks, Marty Adelstein, Dawn Parouse, Neal Moritz and Brett Ratner
Genre: Crime, Drama, Thriller
Airing: Mondays at 8/7c on FOX
Debut Date: August 29, 2005